Cambridge University also won the men's boat race, following on from their victory in the women's race, beating university rivals Oxford University by a factor of two.
It was Cambridge's fifth win in the past six in the men's race and seventh consecutive victory in the women's race.
After the race, Oxford rower Leonard Jenkins said some of his crew had been battling illness.
“This is not to take anything away from Cambridge, but I would also like to say that there were some players who got quite seriously ill with E.coli,” said the Oxford No. 7 player.
“I was throwing up this morning and I wasn't sure if I could race. I kept quiet, but ultimately it's on my shoulders. It wasn't the right choice because I wasn't giving it my all. Maybe.'' I'll yield in that race.
“It would have been better if there wasn't so much poop in the water. I'm not taking credit away from Cambridge because even if they were all in top form, they might not have been able to beat them.”
Both winning teams did not go into the water after their victory, and crew members were instructed to take additional precautions, including covering blisters and wearing footwear when getting on and off the boat.
Men's victory: “It's an unbelievable feeling''
Cambridge dominated the men's race, leading by more than 10 seconds, but slowed down towards the end when Matt Edge nearly collapsed.
However, Edge and his team persevered and emerged victorious.
There were some early warnings about oar collisions, but after about five minutes Cambridge was in the lead by more than a length.
Oxford fell further back, but there was a glimmer of hope when Edge began to struggle in the final straight, barely scraping the water with his oars.
However, a slow start cost them as Cambridge opened up enough distance to hang on.
“This was our last race with the club and we knew it was going to be a difficult race,” said Cambridge president Sebastian Benzukri.
“We put in a lot of effort and pushed ourselves to places we rarely go, but it's an incredible feeling. They never gave up, and I'm so proud of everyone.”
Edge had to be carried off the boat at the end.
Cambridge has an 87-81 advantage in the men's head-to-head race, and Cambridge has a 48-30 lead in the women's race.
Women continue to dominate at Cambridge
Earlier, the Cambridge women's team achieved another clear victory, winning the race for the seventh year in a row.
Oxford were booked after nearly colliding with their opponents. Although he got off to a good start, he was caught up after about 10 minutes and could not recover.
“Once they started we kept believing until the end,” Cambridge University archer Gemma King said.
“We know our pace is our strength and we can catch up.”
Oxford University pilot Joe Guerret lodged an appeal at the end of the race believing that the Cambridge boat had crossed his path, but the appeal was dismissed after discussion with judge Richard Phelps.
Phelps said the Oxford actually traveled to Cambridge Station and collided with the boat.